September/October 2017 – Vol. 30 No. 1

Polio As a Case Study in Science Ethics

Posted: Tuesday, February 3rd, 2015

by Alan Colburn

Imagine for a moment the Ebola virus came to the United States. How do you think people would react? But now imagine scientists had developed a vaccine which they believed would be moderately effective at protecting people from the disease. Now how do you think people would react?

The situation is hypothetical, but the country confronted a similar situation in the 1950s when faced with polio – and a potential vaccine protecting against its spread.

Anyone alive in the 50’s remembers polio and the terror people felt at the possibility they or their children could catch the disease, which was also called infantile paralysis. Places people congregated, like swimming pools, theaters, and even churches, closed during the summer “polio season.” The March of Dimes was created to help fund a cure – ten cents at a time.

The payoff ultimately came when researchers like Jonas Salk and Albert Sabin developed vaccines that would prevent the disease from spreading, if they worked. Like all things scientific, first they needed to be tested. That essentially meant injecting a child, since children were the main victims, with a dead or weakened version of the dreaded polio virus. Today’s analogy would be injecting people with a dead or weakened version of the Ebola virus.

Testing vaccines against diseases such as polio or Ebola raises a panoply of ethical questions:

– Is it ethical to test a vaccine on primates if the only alternative is to do the research on human populations?

– Is it ethical to experiment on vulnerable populations (like children), if they are the group most susceptible to the illness?

– If you had a voice in how limited funds were to be spent, would you encourage rushing something moderately good to market, or use the money to invest in a better solution that would take longer?

– When should large-scale human trials of a vaccine begin, if people are dying and the vaccine might save lives?

For the K-12 science teacher interested in using and applying science practices, perhaps the most relevant questions are about the ethics of biomedical research (including vaccine testing) with placebo control groups. To be able to think about these issues in an informed way, teachers, students, and our entire populace, needs to understand something about different types of experimental designs and the factors researchers must consider when designing valid and reliable experiments. As K-12 science teachers you can help students understand the essential background information and the kinds of questions everyone needs to ask to help us make informed choices. This kind of practical value, in fact, was one of (several) factors considered by NGSS’s creators when deciding what content to include in the new standards.

With something as potentially lifesaving as a polio (or Ebola) vaccine, for example, pundits might make the case everyone should get the medicine. Why test with placebos? Why not experiment with the vaccine, see how many people in the test group were sickened by polio, and just compare the results with those seen during past summers?

The problem with this alternative experimental procedure was that the incidence of polio varied from one year to the next. No one knew why this was, and no one knew what the incidence was “supposed” to be when Salk’s vaccine was being tested. Researchers argued the only way the vaccine could be “fairly” tested would be by comparing its effectiveness against an untreated control group.

Biomedical researchers are confronted with the same dilemmas today. If your child was sick, and an experimental medicine might help, would you want your child to be part of a control group receiving a placebo?

In the case of the polio vaccine, the disease incidence in normal human populations was small enough that a statistically significant test would need to involve sample sizes involving hundreds of thousands of children. The test would need to be double blind, meaning that neither the clinician nor the subjects know who is receiving the vaccine and who the placebo. Assuming the vaccine was safe and effective, children in control groups receiving placebos continued to lack protection against the disease and were essentially being denied a potentially lifesaving treatment.

Ethical dilemmas, by definition, are mutually exclusive options, none of which appears to be completely satisfactory. Critical thinkers should recognize this, and be able to cogently explain the multiple sides of these often controversial issues. As science teachers we can help our students achieve these goals, while providing them with the scientific literacy we all need to make informed decisions, e.g., understanding what “statistical significance” and “double blind testing” means, as well as introducing concepts of antibodies and the immune response.

That said, what happened with the polio vaccine? It’s a rather amazing story. Testing the vaccine was (and is) the largest experiment ever undertaken, involving more than 500,000 research subjects. David Olshinsky tells it well in his Pulitzer Prize winning book Polio: An American Story. Or, if you prefer, The Polio Crusade, an episode of PBS’s American Experience TV series closely follows Olshinsky’s story. It’s available online.

For assistance in thinking through lessons on ethics, The Online Ethics Center for Engineering and Research, sponsored through the National Academies, is a good place to start. The site has a section devoted to ethics in the science classroom, which in turn has information about creating lessons.

Alan Colburn is a professor of science education at California State University, Long Beach, and is a member of CSTA.

Written by Guest Contributor

From time to time CSTA receives contributions from guest contributors. The opinions and views expressed by these contributors are not necessarily those of CSTA. By publishing these articles CSTA does not make any endorsements or statements of support of the author or their contribution, either explicit or implicit. All links to outside sources are subject to CSTA’s Disclaimer Policy: http://www.classroomscience.org/disclaimer.

Leave a Reply

LATEST POST

State Schools Chief Tom Torlakson Announces 2017 Finalists for Presidential Awards for Excellence in Mathematics and Science Teaching

Posted: Wednesday, September 20th, 2017

SACRAMENTO—State Superintendent of Public Instruction Tom Torlakson today nominated eight exceptional secondary mathematics and science teachers as California finalists for the 2017 Presidential Awards for Excellence in Mathematics and Science Teaching (PAEMST).

“These teachers are dedicated and accomplished individuals whose innovative teaching styles prepare our students for 21st century careers and college and develop them into the designers and inventors of the future,” Torlakson said. “They rank among the finest in their profession and also serve as wonderful mentors and role models.”

The California Department of Education (CDE) partners annually with the California Science Teachers Association and the California Mathematics Council to recruit and select nominees for the PAEMST program—the highest recognition in the nation for a mathematics or science teacher. The Science Finalists will be recognized at the CSTA Awards Luncheon on Saturday, October 14, 2017. Learn More…

Written by California Science Teachers Association

California Science Teachers Association

CSTA represents science educators statewide—in every science discipline at every grade level, Kindergarten through University.

Thriving in a Time of Change

Posted: Wednesday, September 13th, 2017

by Jill Grace

By the time this message is posted online, most schools across California will have been in session for at least a month (if not longer, and hat tip to that bunch!). Long enough to get a good sense of who the kids in your classroom are and to get into that groove and momentum of the daily flow of teaching. It’s also very likely that for many of you who weren’t a part of a large grant initiative or in a district that set wheels in motion sooner, this is the first year you will really try to shift instruction to align to the Next Generation Science Standards (NGSS). I’m not going to lie to you, it’s a challenging year – change is hard. Change is even harder when there’s not a playbook to go by.  But as someone who has had the very great privilege of walking alongside teachers going through that change for the past two years and being able to glimpse at what this looks like for different demographics across that state, there are three things I hope you will hold on to. These are things I have come to learn will overshadow the challenge: a growth mindset will get you far, one is a very powerful number, and it’s about the kids. Learn More…

Powered By DT Author Box

Written by Jill Grace

Jill Grace

Jill Grace is a Regional Director for the K-12 Alliance and is President of CSTA.

If You Are Not Teaching Science Then You Are Not Teaching Common Core

Posted: Thursday, August 31st, 2017

by Peter A’Hearn 

“Science and Social Studies can be taught for the last half hour of the day on Fridays”

– Elementary school principal

Anyone concerned with the teaching of science in elementary school is keenly aware of the problem of time. Kids need to learn to read, and learning to read takes time, nobody disputes that. So Common Core ELA can seem like the enemy of science. This was a big concern to me as I started looking at the curriculum that my district had adopted for Common Core ELA. I’ve been through those years where teachers are learning a new curriculum, and know first-hand how a new curriculum can become the focus of attention- sucking all the air out of the room. Learn More…

Powered By DT Author Box

Written by Peter AHearn

Peter AHearn

Peter A’Hearn is the Region 4 Director for CSTA.

Tools for Creating NGSS Standards Based Lessons

Posted: Tuesday, August 29th, 2017

by Elizabeth Cooke

Think back on your own experiences with learning science in school. Were you required to memorize disjointed facts without understanding the concepts?

Science Education Background

In the past, science education focused on rote memorization and learning disjointed ideas. Elementary and secondary students in today’s science classes are fortunate now that science instruction has shifted from students demonstrating what they know to students demonstrating how they are able to apply their knowledge. Science education that reflects the Next Generation Science Standards challenges students to conduct investigations. As students explore phenomena and discrepant events they engage in academic discourse guided by focus questions from their teachers or student generated questions of that arise from analyzing data and creating and revising models that explain natural phenomena. Learn More…

Written by Elizabeth Cooke

Elizabeth Cooke

Elizabeth Cooke teaches TK-5 science at Markham Elementary in the Oakland Unified School District, is an NGSS Early Implementer, and is CSTA’s Secretary.

News and Happenings in CSTA’s Region 1 – Fall 2017

Posted: Tuesday, August 29th, 2017

by Marian Murphy-Shaw

Cal

This month I was fortunate enough to hear about some new topics to share with our entire region. Some of you may access the online or newsletter options, others may attend events in person that are nearer to you. Long time CSTA member and environmental science educator Mike Roa is well known to North Bay Area teachers for his volunteer work sharing events and resources. In this month’s Region 1 updates I am happy to make a few of the options Mike offers available to our region. Learn More…

Written by Marian Murphy-Shaw

Marian Murphy-Shaw

Marian Murphy-Shaw is the student services director at Siskiyou County Office of Education and is CSTA’s Region 1 Director and chair of CSTA’s Policy Committee.